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• Tindall, Donald - Androgen action in prostate cancer.

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Contenido

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

   INDICE: From the contents Introduction: History, Nomenclature, Topic and Author Selection, Goals and Objectives.- 1. The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer.- 2. Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Overview of Research in The Authors’ Laboratory.- 3. Clinical progression to castration-recurrent prostate cancer.- 4. Androgen Metabolism.- 5. Increased expression of genes converting adrenal androgens to testosterone in castration-recurrent prostate cancer.- 6. Androgen metabolic genes in prostate cancer predisposition and progression.- 7. Effect of Steroid 5a -Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer. 8. 5a-Reductase Isozymes in Castration-Recurrent Prostate Cancer.- 9. Androgen Receptor Structure/Function Relationships.

Detalles del artículo

• Páginas : 800
• Editorial : Springer
• Idioma : Inglés
• Fecha de Publicación : 29/06/2009
• ISBN: 9780387691770
• Encuadernación : Cartoné
• Nº Volúmenes : 1
• País de Publicación : Estados Unidos
• Lugar de Publicación : New York