An updated practical guide to the conduct and interpretation of regulatory required acute toxicology testing. It presents protocols for the common test designs and reviews their development and objectives, the types of data they generate, and the status of alternative test designs and models.
CONTENIDO: Acute toxicology programme - study design anddevelopment; tests for dermal irritation and corrosion; ocular irritation testing; dermal sensitization; photosensitization/phototoxicity; lethality testing; safety considerations for the administration of agents by the parenteral routes; acute systemic toxicity tests; routes, formulations, and vehicles; considerations specific to animal test models; statistical analysis for acute toxicology; acute inhalation; problems and issues.
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