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Cutting edge reviews by leaders in the field of apoptosis. Broad coverage of all aspects of programmed cell death. The number of cells within the human body is very tightly regulated: too many and we can develop cancer, too few and we may lose cells that we cannot replace. The number of cells is controlled by several different mechanisms in different tissues, but all are triggered to commit suicide should too many be in one place at one time, or become damaged. This book examines how this process of cell suicide (apoptosis) is regulated, and how our understanding of this process may lead to novel treatments for a wide variety of human diseases.
INDICE: 1 Nicola McCarthy: Why be interested in death? 2 Ding Xue, Yi-ChunWu, Manisha Shah: Programmed cell death in C.elegans: the genetic framework 3 Andreas Bergmann, Hermann Steller: Genetic and molecular analysis of programmed cell death in Drosophila 4 Natalie Roy, Michael Cardone: The caspases: from here to eternity 5 Yoshihide Tsujimoto: Regulation of apoptosis by the Bcl-2 family of proteins 6 Naoufal Zamzami, Santos Susin, Guido Kroemer: Mitochondria in apoptosis: Pandora's Box 7 Paul Clarke: Apoptosis: lessons from free cell systems 8 Nicola McCarthy, Martin Bennett: Death signalling by the CD95/TNFR family of death domain containing receptors 9 Thomas Franke: Survival signalling by phosphorylation: PI3K/Akt sets the stage 10 David Vaux: Viruses and apoptosis 11 Michael Jacobson, Louise Bergeron: Cell death in the nervous system.
Postgraduate students in cell biology, postdocs new to the field, advanced undergraduates; postgraduate medical students/clinicians undertaking research training in the area.
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