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Contenido

This book covers ageing from a fundamental cell biological perspective. The evolution and developmental genetics of senescence are explained clearly. All the various theories of ageing -- the Hayflick limit and telomeric shortening as a possible biological clock, the impacts of somatic mutations, oxidative stress, accumulation of waste materials in cells with age -- are explained and critically assessed. The author presents vivid case accounts about disorders that open windows on to the ageing process. The impacts of ageing on the brain and nervous system are given special attention, as are the effects of caloric restriction on maximum lifespan.

   INDICE: Introduction 1 Aging and Senescence 2 The Nature of Cellular Death3 The Evolution of Senescence and Lifespan 4 Of Embryos and Old Men: The Developmental Genetics of Senescence and Lifespan 5 Human Genetic Diseases that Mimic the Aging Process 6 Cycling to Senescence 7 Replicative Immortality: Cancer and Aging 8 Caloric Restriction and Maximum Possible Lifespan 9 Oxidative Stress and Cellular Senescence 10 The Aging Brain 11 A Conditional Benefit.

Detalles del artículo

• Páginas : 256
• Editorial : Oxford University Press
• Idioma : Inglés
• Fecha de Publicación : 01/04/2002
• ISBN: 9780195153750
• Encuadernación : Rústica
• Nº Volúmenes : 1
• País de Publicación : Reino Unido (INGLATERRA)
• Lugar de Publicación : Oxford