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Contenido

Pharmacokinetics describes what the body does to a drug: it involves the processes of drug absorption. biotransformation/metabolism. distribution. and elimination. This subject provides the basis for understanding how drugs produce their effects, and patient responses.

   INDICE: Groundwork. general introduction of physiological modelling and compartmental analysis. Routes of administration and drug absorption. drug distribution. Drug elimination. Linear one-compartment model with instantaneous input and first-order output. Linear one-compartment model with zero-order input and first-order output. Linear one-compartment model with zero-order input and first-order output. Analysis of urinary data. Linear one-compartment model - multiple dosing kinetics. Linear two-compartment model with instantaneous input and first-order output. linear two-compartment model - multiple dosing kinetics. General approaches of dosage adjustment for patients with renal impairment. effect of dialysis of pharmacokinetics of drugs. Bioavailablility of bioequivalence evaluation. Noncompartmental approach in pharmacokinetics based on statistical moments. Appendix: Answers to assignments.

Detalles del artículo

• Páginas : 528
• Editorial : Mcgraw-Hill/Interamericana
• Idioma : Inglés
• Fecha de Publicación : 01/08/2001
• ISBN: 9780071351645
• Encuadernación : Cartoné
• Nº Volúmenes : 1
• País de Publicación : Estados Unidos