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• Hughes, Timothy R. - A handbook of transcription factors

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Contenido

Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes.á In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution.á. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution ofspecific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Soup-to-nuts overview not provided by any other book. Objective, high-level, genome-based viewpoint, with subsidiary examples, rather than “paradigm by anecdote”. Combines in-depth analysis of molecular biology literature with computational-based large-scale analyses.

   INDICE: Preface. 1 Introduction to A Handbook of Transcription Factors, Timothy R. Hughes. 2 An Index of Prokaryotic Transcription Factors, Karthikeyan Sivaraman et al. 3 A Catalogue of Eukaryotic Transcription Factor Types, theirEvolutionary Origin, and Species Distribution, Matthew T. Weirauch and Timothy R. Hughes. 4 Function and Evolution of C2H2 Zinc Finger Arrays, Lisa Stubbs,Younguk Sun and Derek Caetano-Anolles. 5 Homeodomain Sybtypes and Functional Diversity, Thomas R. Bürglin. 6 Nuclar Receptors, Keith Pardee, Aleksander S. Necakov, Henry Krause. 7 Methods for Analysis of Transcription Factor DNA-binding Specificity in vitro , Arttu Jolma, Jussi Taipale. 8 Identification of Transcription Factor-DNA Interactions in vivo , Duncan T. Odom. 9 How Transcription Factors Identify Regulatory Sites in Genomic Sequence, Yair Field, Eilon Sharon, Eran Selgal. 10 Transcription Factor in Binding Sites and other Featuresin Human and Drosophila Proximal Promoters, Charles Vinson, Raghunath Chatterjee, Peter Fitzgerald. 11 Interactions of Transcription Factors with Chromatin, Harm van Bakel. 12 Transcription Factors Effector Domains, Seth Frietze, Peggy J. Farnham. 13 Large-scale Nuclear Architecture and Transcriptional Control, Juan M. Vaquerizas, Asifa Akhtar, Nicholas M. Luscombe. Index

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• Formato: PDF - Adobe DRM
• Tamaño: 7,62 Mb
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Detalles del artículo

• Páginas: 250
• Capítulos: 13
• Editorial: Springer Netherlands
• Idioma: Inglés
• Fecha de Publicación: 01/04/2011
• ISBN: 9789048190690
• Serie: Subcellular biochemistry 52
• País de Publicación: Holanda
• Lugar de Publicación: Dordrecht