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• Dougherty, Thomas J. - Antibiotic discovery and development

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Contenido

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for newantibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before ina single reference. With the rise of antibiotic resistance and the increasingview that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook isto offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Chapters written by experts in their fields. Contains helpful, full-color illustrations. Features up-to-date research.

   INDICE: Introductory History of Antimicrobial Drugs. Marketed Major Classes of Compounds. The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes. Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes. Antibiotic Discovery. Antibiotic Drug Development. The Economics and Incentives of Antibiotic Drug Discovery.

Formato/ permisos

• Formato: PDF - Adobe DRM
• Tamaño: 18,75 Mb
• Copiar y Pegar: 179 páginas al día
• Imprimir: 179 páginas al día
• Fecha de Expiración: No expira
• Lectores: PCs, Macs y lectores compatibles con Adobe DRM
• Software Requerido: Adobe Digital Editions
• Política de Devoluciones: No se admiten devoluciones
• Material Anejo: No se incluye

Detalles del artículo

• Páginas: 1251
• Capítulos: 37
• Editorial: Springer US
• Idioma: Inglés
• Nº Edición: 2012
• Fecha de Publicación: 28/12/2011
• ISBN: 9781461414001
• País de Publicación: Estados Unidos
• Lugar de Publicación: Boston, MA